Institutional Animal Care and Use Committee
The University
of Illinois at Urbana-Champaign
Institutional Animal Care and Use Committee |
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The University
of Illinois at Urbana-Champaign
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An example of a search for available alternatives in polyclonal antibody production:
Database Searched:
BIOSIS Previews (1980 - 3/98)
Date of Search:
6/16/98
Search Strategy:
"Antibod*" = 267,349 records
"Freund*" = 6,525 records
"Alternative" = 59,131 records
The combination of the above terms
= 29 records.
Results:
Of the 29 titles retrieved, 6 appeared
relevant to the topic of alternatives to Freund's Complete Adjuvant in polyclonal
antibody production.
Titles Found (bold indicates relevancy):
1. The immunotargeting approach to adjuvant-independent immunization with influenza haemagglutinin.2. Comparison of conventional adjuvants and "adjuvant-free" monoclonal antibody targeting for stimulating antibody responses against a conjugate of luteinizing hormone releasing hormone and avidin.
3. Evaluation of subcutaneous chambers as an alternative to conventional methods of antibody production in chickens.
4. A comparison of commercially available adjuvants for use in research.
5. A potential vaccine for cocaine abuse prophylaxis.
6. Evaluation of several adjuvants as alternatives to the use of Freund's adjuvant in rabbits.
7. Detection and quantification of secreted soluble Fc-gamma-RIIA in human sera by an enzyme-linked immunosorbent assay.
8. The influence of various adjuvants on antibody synthesis following immunization with an hapten.
9. Active immunization with cocaine-protein conjugate attenuates cocaine effects.
10. Maternal monoclonal antibody to the V3 loop alters specificity of the response to a human immunodeficiency virus vaccine.
11. The laying hen as an antibody source: Experiences with husbandry systems, immunization and egg yield.
12. Immune response to 17-beta-estradiol in polyelectrolyte complex: Antigen specificity and affinity of hybridoma clones.
13. An investigation into the immunogenicity of a GnRH analogue in male rats: A comparison of the toxicity of various adjuvants used in conjunction with GnRH-glycys.
14. Comparison of adjuvants for immune potentiating properties and side effects in mice.
15. Prevention of Experimental Allergic Encephalomyelitis in Rats by Targeting Autoantigen to B Cells: Evidence That the Protective Mechanism Depends on Changes in the Cytokine Response and Migratory Properties of the Autoantigen-specific T Cells.
16. Induction of humoral and cellular immunity to simian immunodeficiency virus: What are the requirements for protection?
17. Immune responses following cocktails of inactivated measles vaccine and Arachis hypogaea L. (groundnut) or Cocos nucifera L. (coconut) oils adjuvant.
18. The thyroperoxidase doublet is not produced by alternative splicing.
19. Effect of varying dosages and adjuvants on antibody response in squirrel monkeys (Saimiri sciureus) immunized with the porcine zona pellucida M-r equals 55000 glycoprotein (ZP3).
20. Immunization of sheep against modified peptides of gonadotropin releasing hormone conjugated to carriers.
21. Immunization of cattle against modified peptides of gonadotropin releasing hormone conjugated to carriers: Effectiveness of Freund's and alternative adjuvants.
22. Treatment with natural human interferon alpha of a CML-patient with antibodies to recombinant interferon alpha-2b.
23. Successful vaccination against murine Schistosoma mansoni infection with a purified 12-Kd Fasciola hepatica cross-reactive antigen.
24. Treatment of experimental autoimmune myasthenia gravis in rabbits with leupeptin, a protease inhibitor.
25. Evaluation of ethylene-vinyl acetate copolymer as a non-inflammatory alternative to Freund's complete adjuvant in rabbits.
26. Attempted immunization of swine against acute sarcocystosis using cystozoite-derived vaccines.
27. Induction of contact sensitivity to a broad variety of allergens with haptenized macrophages.
28. Development of monoclonal antibodies to proteins separated by 2-dimensional gel electrophoresis.
29. Antigen recognition by thymus-derived cells and bone marrow-derived cells: Recognition of cross-reactivity between native and denatured forms of globular antigens.
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