University of Illinois at Urbana-Champaign
DIVISION OF ANIMAL RESOURCES and
AGRICULTURAL ANIMAL CARE AND USE PROGRAM

Amending Animal Use Protocols

Any change in a project involving animals requires additional review by the Institutional Animal Care and Use Committee (IACUC) or staff, and may not be undertaken until approval has been granted. Changes may be either minor or significant.

Minor amendments
Minor amendments include any of the following:

• Project title or Funding source
• Addition or removal of project personnel, except for Principal Investigator
• Addition of new animal genetic background or strain, where change does not include new transgenic strains or impact animal care. A change from rodents to dogs would not be considered minor.
• Increase in number of animals; additions are limited to =10% of number originally approved for each species at a given time.
• Change in animal care facility, housing unit or field site to other approved location.
• Change in administration of experiment/treatment as it relates to timing, dose, route of administration and/or specific chemical composition, where change does not alter the invasiveness of the procedure, specific objective(s), or scientific rationale.
• Disposition of animals at the end of the study.

To make the above changes, a Minor Amendment Form is available. If anyone other than the PI is submitting the form, the PI must also be copied to the PI, and this must be clear in the email submitted to the IACUC. (Use the cc: option in your e-mail program!). The minor amendment form requires the same completeness as the animal use protocol. All changes must be fully described and justified. Experience and/or training of new personnel in the procedures they are to perform must be described.

Significant amendments:
Significant amendments must be submitted by e-mail by the principal investigator (or copied to him/her) to the Institutional Animal Care and Use Committee main email address (iacuc@iacuc.uiuc.edu). The e-mail should reference by number and/or title the protocol to be amended, and provide a summary and justification for all requested changes. Submissions must include sufficient information for the IACUC to evaluate changes using the same criteria as in the initial review. Attached to the e-mail must be a revision of the previously submitted and approved IACUC-1 form. The complete details of the proposed amendment must be incorporated into the revised IACUC-1 form. Revised text should be clearly indicated in bold, underlined, or italicized fonts, or be preceded by a dateline.

All changes must be fully described and justified. For instance, if a surgical procedure is to be added, the request must describe pre- and post-operative care of the animal; preparation of the surgeon, instruments, and the animal; anesthetics and post-operative analgesics, their dosages and route of administration, etc. If an increase in animal numbers greater than 10% of the original number approved is requested, the PI must provide the reasons for the need of additional animals and justification for the number requested. Reviews of significant amendments by the IACUC do not differ from reviews of full protocols.

IACUC
Room 114 Observatory (MC-193)
901 S. Mathews Avenue
Urbana, IL 61801
iacuc@iacuc.uiuc.edu